ADJUVANT PUBLICATIONS & ABSTRACTS

Adjuvant data

Evidence / Adjuvant

Metastatic Potential of T1 Breast Cancer Can Be Predicted by the 70-gene MammaPrint Signature

PUBLICATION: Ann Surg Oncol. 2010 May;17(5):1406-13. doi: 10.1245/s10434-009-0902-x. Epub 2010 Jan 22. AUTHORS: Mook S., Knauer M., Bueno-de-Mesquita J.M., Retel V.P., Wesseling J., Linn S.C., Van't Veer L.J., Rutgers E.J. SUMMARY: The 10-year distant metastasis-free (DMFS) and breast cancer specific survival (BCSS) probabilities were 87% (SE 2%) and 91% (SE Read More

The Predictive Value of the 70-Gene Signature for Adjuvant Chemotherapy in Early Breast Cancer

PUBLICATION: Breast Cancer Res Treat. 2010 Apr;120(3):655-61. doi: 10.1007/s10549-010-0814-2. AUTHORS: Knauer M., Mook S., Rutgers E.J., Bender R.A., Hauptmann M., van de Vijver M.J., Koornstra R.H., Bueno-de-Mesquita J.M., Linn S.C., van 't Veer L.J. ABSTRACT: Multigene assays have been developed and validated to determine the prognosis of breast cancer. In Read More

The 70-gene Prognosis Signature Predicts Early Metastasis in Breast Cancer Patients Between 55 and 70 Years of Age

PUBLICATION: Ann Oncol. 2010 Apr;21(4):717-22. doi: 10.1093/annonc/mdp388. Epub 2009 Oct 13. AUTHORS: Mook S., Schmidt M.K., Weigelt B., Kreike B., Eekhout I., van de Vijver M.J., Glas A.M., Floore A., Rutgers E.J., van 't Veer L.J. SUMMARY: The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 Read More

Clinical Application of the 70-gene Profile: The MINDACT Trial

PUBLICATION: J Clin Oncol. 2008 Feb 10;26(5):729-35. doi: 10.1200/JCO.2007.14.3222. AUTHORS: Cardoso F., Van't Veer L., Rutgers E., Loi S., Mook S., Piccart-Gebhart M.J. SUMMARY: Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the Read More

Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort.

PUBLICATION: Clin Cancer Res. 2008 May 15;14(10):2988-93. doi: 10.1158/1078-0432.CCR-07-4723. AUTHORS: Wittner B.S., Sgroi D.C., Ryan P.D., Bruinsma T.J., Glas A.M., Male A., Dahiya S., Habin K., Bernards R., Haber D.A., Van't Veer L.J., Ramaswamy S. SUMMARY: The MammaPrint assay was originally designed to identify younger breast cancer patients at low Read More

Use of 70-gene Signature to Predict Prognosis of Patients with Node-Negative Breast Cancer: A Prospective Community-Based Feasibility Study (RASTER)

PUBLICATION: Lancet Oncol. 2007 Dec;8(12):1079-1087. doi: 10.1016/S1470-2045(07)70346-7. Epub 2007 Nov 26. AUTHORS: Bueno-de-Mesquita J.M., van Harten W.H., Retel V.P., van't Veer L.J., van Dam F.S., Karsenberg K., Douma K.F., van Tinteren H., Peterse J.L., Wesseling J., Wu T.S., Atsma D., Rutgers E.J., Brink G., Floore A.N., Glas A.M., Roumen R.M., Read More

Individualization of Therapy Using MammaPrint: from Development to the MINDACT Trial

PUBLICATION: Cancer Genomics & Proteomics. 2007 May-Jun;4(3):147-55. AUTHORS: Mook S., Van't Veer L.J., Rutgers E.J., Piccart-Gebhart M.J., Cardoso F. SUMMARY: A narrative review of the development and validation of MammaPrint. Read more: Mook et al_2007_Cancer Genomics & Proteomic_Individualization-of-Therapy

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