“While chemotherapy is often assumed to be necessary for all young women with hormone receptor positive breast cancer, we have been able to harness the power of gene expression profiling to understand the biology of each breast cancer beyond the effects of age and standard pathology, and better define the true benefit of treatment. These insights could allow some young women with breast cancer to forgo chemotherapy and avoid unnecessary toxicity,” said William Audeh, MD, Chief Medical Officer at Agendia. “If their small chemotherapy benefit indeed stems from OFS as the PROOF Registry trial seeks to prove, more young women can forgo the potentially serious and sometimes life-threatening effects of chemotherapy. We’re proud to partner with WSG on this important step to advance personalized treatment planning, reduce overtreatment, and help more women with breast cancer maintain their quality of life.”
The PROOFS Registry trial intends to enroll 1,500 patients via 100 sites in Germany by January 2025. Right now, it is critical young women with early breast cancer be afforded the opportunity for shared decision-making when weighing the small perceived chemotherapy benefit against its impact on their future fertility and quality of life. By the close of the PROOFS Registry study, providers may be in a position to confidently recommend OFS as an alternative to toxic chemotherapy and preserve a woman’s fertility while maintaining the best chance at survival. Together with WSG, Agendia continues to enable more personalized treatments in breast cancer care.
Agendia is a mission-driven, commercial stage company focused on enabling optimized decision-making by providing physicians with next-generation diagnostic and information solutions that can be used to help improve outcomes for breast cancer patients worldwide. The company currently offers two commercially-available genomic profiling tests that help surgeons, oncologists and pathologists to personalize treatment for women at critical intervention points throughout their patient journey.
MammaPrint® is a 70-gene prognostic test that, along with other clinicopathologic factors, determines a specific patient’s breast cancer recurrence risk. BluePrint® is an 80-gene molecular subtyping test that identifies the underlying biology of an individual breast cancer to provide information about its behavior, long-term prognosis and potential response to systemic therapy. Together, MammaPrint® and BluePrint® provide a holistic view of the biology underlying an individual patient’s breast cancer, enabling physicians to objectively select the best treatment plan.
About the West German Study Group (WSG)
The West German Study Group (WSG) is a collaborative research group that focuses on the design, organization, and implementation of clinical studies in the field of breast cancer. The goals of its studies are to optimize existing therapies in terms of effectiveness and tolerability, avoid unnecessary therapies and individualize breast cancer therapy.
For more information on Agendia’s assays and ongoing trials, please visit www.agendia.com.
For more information on WSG’s activities and ongoing trials, please visit wsg-online.com.