HER2-Type cancers are primarily driven by the HER2 receptor pathway. This molecular subtype does not always align with IHC- or FISH-derived HER2 results but HER2-Type patients have excellent response to HER2-targeted therapies in the neoadjuvant setting. In fact, with advances in therapeutics, HER2-Type patients have good long term outcomes when treated with HER2-targeted agents.