By Ryan Scott June 1, 2024
Key Takeaways
- Patients with MammaPrint high-2, BluePrint Luminal B, HR-positive, HER2-negative early breast cancer had better 3-year RFS with anthracycline plus a taxane and cyclophosphamide.
- Luminal MP high-1–risk patients had comparable 3-year RFS rates with both anthracycline-based and non-anthracycline regimens.
Treatment with anthracycline plus a taxane and cyclophosphamide was linked to a lower risk of recurrence at 3 years in patients with MammaPrint (MP) high-2, BluePrint Luminal B, hormone-receptor (HR)–positive, HER2-negative early breast cancer, according to data from the prospective, observational, nonrandomized FLEX registry trial (NCT03053193) presented at the 2024 ASCO Annual Meeting.
Findings showed that patients with Luminal MP high-1–risk disease had comparable 3-year recurrence-free survival (RFS) rates when treated with a taxane and cyclophosphamide (n = 346) at 97.1% (95% CI, 95.1%-99.2%) and with anthracycline plus a taxane and cyclophosphamide (n = 184) at 95.3% (95% CI, 91.8%-98.8%). However, patients with Luminal MP high-2–risk disease had a worse 3-year RFS rate when treated with the 2-drug regimen (n = 40) at 86.4% (95% CI, 74.2%-100%) compared with the anthracycline regimen (n =44) at 97.7% (95% CI, 93.4%-100%).
“In the real-world FLEX registry trial, patients with MammaPrint high-2–risk, BluePrint Luminal B, HR-positive, HER2-negative early breast cancer had a higher 3-year RFS rate with anthracycline plus a taxane and cyclophosphamide than with a taxane and cyclophosphamide therapy in this non-randomized cohort,” Joyce O’Shaughnessy, MD, explained in a presentation of the data. “Luminal MammaPrint high-1–risk patients had similar 3-year RFS rates with an adjuvant taxane and cyclophosphamide [compared] with anthracycline plus a taxane and cyclophosphamide.”
Link to article here.
