Irvine, CA

February 4, 2021

Location: Irvine, CA

Department: Product Support

Reports To: Sr. Director, Product Support   

FLSA Status: Exempt

Job Summary:

The Bioinformatician II contributes to Product Support’s two main goals: supporting existing microarray and NGS-based cancer diagnostic testing products on the market, and assisting in the transition of new products from research and development to the market.

Essential Duties and Responsibilities:

  • Perform analysis of high-throughput microarray and Next Generation Sequencing [NGS]) – based biological data
  • Actively participate in multidisciplinary teams to execute assigned projects, including:
    • Support existing products by addressing internal and external requests
    • Detect, monitor, and investigate issues observed in Laboratory Operations, determine if diagnostic results are affected, and find solutions if necessary
    • Transfer new products from Research through Product Development to Laboratory Operations
    • Identify and validate process and product improvements, e.g. to reagents, workflows, equipment, algorithms, and software
    • Support ongoing Clinical Study data analysis and software development and maintenance
  • Communicate project status and analysis results in a clear, concise manner to the relevant audience
  • Ensure compliance with CAP, CLIA, ISO and FDA regulations and oversight
  • Follow all Agendia health and safety policies and procedures
  • Assists the Senior Director, Product Support in planning and directing the technical work of other members of Product Support
  • Advises the other members of Product Support on more challenging and/or problematic projects
  • Exercises independent judgement, discretion, initiative, and resourcefulness in defining and executing Product Support projects
  • Performs other related duties as required or assigned

Contacts:

This position may interact with all departments within the company, especially Lab Operations, Regulatory Affairs and Quality Assurance, Research and Development, and Clinical/Medical Affairs; as well as external collaborators and the scientific community.

Education and Experience Requirements:

  • Ph.D. in computer science, statistics, or life science with a strong background in bioinformatics
  • Minimum of 5 years of relevant experience
  • Minimum of 2 years commercial company experience preferred but not required
  • Experience with molecular diagnostic testing and with either microarray or NGS bioinformatics preferred but not required
  • Experience working in a regulated CLIA/CAP environment preferred but not required
  • Experience with Cell Free Liquid Biopsy and Whole Exome NGS data analysis will enhance qualifications

Skills and Qualifications Requirements:

  • Technical
    • Strong programming experience in R, familiar with other languages (preferably Matlab and Python) and ability to rapidly acquire competence in other languages as needed
    • Sound knowledge of bioinformatics, as well as theoretical and applied statistics and molecular biology applications
    • Knowledge of analysis methods for high-throughput data such as microarrays and NGS, preferably in the context of gene expression.  Experience with cell-free liquid biopsy and whole exome NGS data analysis will enhance qualifications.
    • Familiar with the Microsoft Windows environment and Office applications
    • Familiarity with the Linux command-line environment
  • Non-Technical
    • Strong problem-solving skills – able to quickly collect information to assess a problem, apply personal experience and expert opinions from others to find a solution, and implement the solution quickly and accurately
    • Strong communication skills – able to fully comprehend complex topics, while being able to distill that knowledge into a clear, concise summary for laypeople
    • Strong time management skills – able to work on multiple projects with minimal guidance and prioritizing them based on department and company needs.  Maintaining progress on long-term projects in the face of urgent tasks
    • Organized and detail-oriented
    • Can do-attitude; enables change
    • Ability and interest in mentoring colleagues

Supervisory Responsibilities

  • This position requires mentoring but has no supervisory responsibilities.

Environment/Safety/Work Environment:

  • General office environment.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  • Maintains a clean, neat, and orderly work area.
  • Adheres to department-specific safety guidelines.

Physical Demands:

  • Standing, sitting, walking, bending, reaching, manual manipulation, and lifting up to 10 pounds.
  • All candidates must pass a color vision test

Job Summary:

The Bioinformatician II contributes to Product Support’s two main goals: supporting existing microarray and NGS-based cancer diagnostic testing products on the market, and assisting in the transition of new products from research and development to the market.

Essential Duties and Responsibilities:

  • Perform analysis of high-throughput microarray and Next Generation Sequencing [NGS]) – based biological data
  • Actively participate in multidisciplinary teams to execute assigned projects, including:
    • Support existing products by addressing internal and external requests
    • Detect, monitor, and investigate issues observed in Laboratory Operations, determine if diagnostic results are affected, and find solutions if necessary
    • Transfer new products from Research through Product Development to Laboratory Operations
    • Identify and validate process and product improvements, e.g. to reagents, workflows, equipment, algorithms, and software
    • Support ongoing Clinical Study data analysis and software development and maintenance
  • Communicate project status and analysis results in a clear, concise manner to the relevant audience
  • Ensure compliance with CAP, CLIA, ISO and FDA regulations and oversight
  • Follow all Agendia health and safety policies and procedures
  • Assists the Senior Director, Product Support in planning and directing the technical work of other members of Product Support
  • Advises the other members of Product Support on more challenging and/or problematic projects
  • Exercises independent judgement, discretion, initiative, and resourcefulness in defining and executing Product Support projects
  • Performs other related duties as required or assigned

Contacts:

This position may interact with all departments within the company, especially Lab Operations, Regulatory Affairs and Quality Assurance, Research and Development, and Clinical/Medical Affairs; as well as external collaborators and the scientific community.

Education and Experience Requirements:

  • Ph.D. in computer science, statistics, or life science with a strong background in bioinformatics
  • Minimum of 5 years of relevant experience
  • Minimum of 2 years commercial company experience preferred but not required
  • Experience with molecular diagnostic testing and with either microarray or NGS bioinformatics preferred but not required
  • Experience working in a regulated CLIA/CAP environment preferred but not required
  • Experience with Cell Free Liquid Biopsy and Whole Exome NGS data analysis will enhance qualifications

Skills and Qualifications Requirements:

  • Technical
    • Strong programming experience in R, familiar with other languages (preferably Matlab and Python) and ability to rapidly acquire competence in other languages as needed
    • Sound knowledge of bioinformatics, as well as theoretical and applied statistics and molecular biology applications
    • Knowledge of analysis methods for high-throughput data such as microarrays and NGS, preferably in the context of gene expression.  Experience with cell-free liquid biopsy and whole exome NGS data analysis will enhance qualifications.
    • Familiar with the Microsoft Windows environment and Office applications
    • Familiarity with the Linux command-line environment
  • Non-Technical
    • Strong problem-solving skills – able to quickly collect information to assess a problem, apply personal experience and expert opinions from others to find a solution, and implement the solution quickly and accurately
    • Strong communication skills – able to fully comprehend complex topics, while being able to distill that knowledge into a clear, concise summary for laypeople
    • Strong time management skills – able to work on multiple projects with minimal guidance and prioritizing them based on department and company needs.  Maintaining progress on long-term projects in the face of urgent tasks
    • Organized and detail-oriented
    • Can do-attitude; enables change
    • Ability and interest in mentoring colleagues

Supervisory Responsibilities

  • This position requires mentoring but has no supervisory responsibilities.

Environment/Safety/Work Environment:

  • General office environment.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  • Maintains a clean, neat, and orderly work area.
  • Adheres to department-specific safety guidelines.

Physical Demands:

    • Standing, sitting, walking, bending, reaching, manual manipulation, and lifting up to 10 pounds.
    • All candidates must pass a color vision test