Clinical and Scientific Evidence for MammaPrint + BluePrint

Evidence

ESMO 2020: UltraLow Data from the IKA Cohort

PUBLICATION: ESMO 2020 AUTHORS: Mark Opdam, Vincent van der Noort, Miranda Kleijn, Anuska Glas, Ingrid Mandjes, Dinja Kruger, Paul van Diest, Jan Vermorken, Harm van Tinteren, Sabine Linn Background: Adjuvant tamoxifen is widely used as endocrine treatment for oestrogen receptor positive (ER+) breast cancers (BC). Guidelines recommend the use of Read More

ESMO 2020 – Hallmarks of Cancer

PUBLICATION: ESMO 2020 AUTHORS: Josien C. Haan, Rajith Bhaskaran, Lorenza Mittempergher, Ersan Lujinovic, William Audeh, Frederique Penault-Llorca and Annuska M. Glas Background: MammaPrint® (MP) is a 70-gene based assay that stratifies early-stage breast cancer (EBC) patients into low and high-risk of relapse. BluePrint® (BP) is an 80-gene based assay that Read More

Cost-effectiveness analysis of the 70-gene signature compared with clinical assessment in breast cancer based on a randomised controlled trial

PUBLICATION: European Journal of Cancer AUTHORS: Laurent Jacob, Anke Witteveen, Inès Beumer, Leonie Delahaye, Diederik Wehkamp, Jeroen van den Akker, Mireille Snel, Bob Chan, Arno Floore, Niels Bakx, Guido Brink, Coralie Poncet, Jan Bogaerts, Mauro Delorenzi, Martine Piccart, Emiel Rutgers, Fatima Cardoso, Terence Speed, Laura van ’t Veer, and Annuska Read More

Controlling Technical Variation Amongst 6693 Patient Microarrays of the Randomized MINDACT Trial

PUBLICATION: Communications Biology AUTHORS: Laurent Jacob, Anke Witteveen, Inès Beumer, Leonie Delahaye, Diederik Wehkamp, Jeroen van den Akker, Mireille Snel, Bob Chan, Arno Floore, Niels Bakx, Guido Brink, Coralie Poncet, Jan Bogaerts, Mauro Delorenzi, Martine Piccart, Emiel Rutgers, Fatima Cardoso, Terence Speed, Laura van ’t Veer, and Annuska Glas Abstract: Read More

ASCO 2020: Chemokine Signature

PUBLICATION: ASCO 20 AUTHORS: Hatem Soliman, Sangeetha Prabhakaran, Marilin Rosa, Charles Cox, Pat Whitworth, Sahra Uygun, Heather M. Kling, Erin B. Yoder, and William Audeh SUMMARY: Studies demonstrating the presence of immunoregulatory gene activation1 and tumor- infiltrating lymphocytes in the breast tumor microenvironment suggest the importance of an effective anti-tumor Read More

ASCO 2020: TNBC Subtype

PUBLICATION: ASCO 20 AUTHORS: Virginia G. Kaklamani, Cathy Graham, Karen L. Tedesco, Abirami Sivapiragasam, Jennifer Crozier, Apurva N. Shah, Andrea Menicucci, Shiyu Wang, Michelle L. Bolner, Erin Yoder, William Audeh, FLEX Investigators' Group SUMMARY: Triple negative breast cancer (TNBC) is an aggressive histological subtype with few targeted therapies and worse Read More

ASCO 2020: 8q22 Poster

PUBLICATION: ASCO 20 AUTHORS: Sami Diab, Matei P. Socoteanu, Carlos A. Encarnacion, Cynthia R. C. Osborne, Carolyn B. Hendricks, Kristi McIntyre, Vibha Taneja Thomas, Rajith Bhaskaran, Josien Haan, Lorenza Mittempergher, Andrea Menicucci, William Audeh, Joyce O'Shaughnessy, FLEX Investigators’ Group SUMMARY: Previous studies have shown that CCNE2 expression is higher in Read More